Metastatic Biphasic Primitive Tumor in the Mandible of a Child.

Pediatric mandibular tumors present an aggressive biological behavior and difficult diagnosis. A wide range of odontogenic and nonodontogenic tumors comprise the spectrum of these lesions. We report a case of a 1-year-old male child patient showing facial asymmetry symptomatic of an expansive lesion extending throughout the body and ramus of the left hemimandible with a diameter of 8 cm. The histopathological report suggested a high-grade mucoepidermoid carcinoma (MEC), recommending further immunohistochemical investigation of the ectomesenchymal or neuroectodermal origin of the tumor cells. The patient evolved with extensive bilateral pleural effusion followed by metastasis in the middle third of the right humerus, and died 2 months after the first biopsy procedure by acute renal failure with tubular necrosis, before a final inconclusive immunohistochemical report was reached. The lack of resources for less-favored regions of Brazil impairs rapid biomolecular examinations such as immunohistochemical resulting in delay of appropriate therapeutic procedures.

Association of taste receptor gene polymorphisms with dental caries.

This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children's systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39-2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11-1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02-1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries.

Association of taste receptor gene polymorphisms with dental caries

Abstract This study was performed to evaluate the interplay between dental caries, nutritional status, and genetic polymorphisms in TAS1R1 and TAS1R2 (taste receptor, type 1, member 1 and 2) in preschool children and pre-adolescents. We included 525 subjects (306 preschool children and 219 pre-adolescents). Parents/caregivers answered a self-administered questionnaire about their children's systemic health, characteristics, oral hygiene habits, and diet. Clinical examination was performed to evaluate dental caries and nutritional status. Saliva samples were collected for DNA extraction. The genotyping of rs17492553 ( TAS1R1 ), rs3935570, and rs4920566 ( TAS1R2 ) polymorphisms was performed using real-time PCR with Taqman Genotyping Master Mix and SNP assay. Both univariate and multivariate Poisson regression analyses with robust variance were used for the data analysis. In preschool children, consumption of sweets between meals increased the prevalence of dental caries by 85% (PR c = 1.85; 95%CI 1.39-2.46; p < 0.001), whereas in pre-adolescents, this prevalence increased by 34% (PR a = 1.34; 95%CI 1.11-1.62; p = 0.002), regardless of genetic polymorphisms . Moreover, individuals carrying at least one allele C in rs17492553 presented 23% more prevalence of dental caries (PR a = 1.23; 95%CI 1.02-1.49 p = 0.030). Nutritional status was not associated with dental caries, neither with genetic polymorphisms . Consumption of sweets between meals increased the prevalence of dental caries. In pre-adolescents, rs17492553 genetic polymorphism in TAS1R1 was associated with dental caries.

Knowledge of parents/caregivers about the sleep bruxism of their children from all five Brazilian regions: A multicenter study.

BACKGROUND: Sleep bruxism (SB) is a masticatory muscle activity that affects children. Parents' knowledge is important for its identification and report to dentists. AIM: To investigate parents' knowledge about SB among their children. DESIGN: A cross-sectional study included 1325 parents of children from dental clinics of seven institutions from all regions of Brazil. Parents answered questions about child's sleep, knowledge about SB and its occurrence among children and parents. SB definition given by parents was dichotomized as "correct"/"incorrect", based on the American Academy of Sleep Medicine definition. Descriptive, bivariate and multivariate analyses were performed (P < 0.05). RESULTS: Most parents (57.3%) did not know what SB is and 88.9% would like to receive more information. SB prevalence among parents was 15.4% and 24.0% among children. Between parents who correctly defined SB, its prevalence increased to 27.5% among parents and 40.6% among children. Parents whose children had/have SB, who would like to receive more information about SB and were from the North, Central-West, Southeast, and South regions were more likely to define SB correctly (P > 0.05). CONCLUSION: There is a lack of knowledge of parents about SB. SB among children, parents' interest in receiving more information and their location were factors associated to their knowledge.

Timing of Permanent Tooth Emergence is Associated with Overweight/Obesity in Children from the Amazon Region.

The aim of this study was to evaluate the association between timing of permanent tooth emergence with overweight and obesity in children from Brazilian Amazon region. The studied population consisted of 192 children, 09 to 12 year-old, from public schools at Manaus, Amazonas-Brazil. Clinical examination was performed and the tooth emergence was evaluated according to the number of permanent erupted teeth. Body mass index z-score was calculated. For the statistical analysis 'Overweight/obese' group was compared with 'Normal weight' group in a case to control ratio 1:2. The t-test based on age was used for means comparison between the groups. A linear regression analysis using age and gender as co-variants was used. The established alpha was 5%. One hundred twenty-seven children were classified as normal weight and 65 were classified as overweight/obese (49 were overweight and 16 were obese). Overweight/obesity condition was associated with the gender, in which boys had a higher chance to present higher weight conditions (OR=1.84; CI 95% 1.06-3.37; p=0.04). The mean number of permanent teeth was higher in the overweight/obesity group (p<0.001). Linear regression analysis demonstrated that nutritional status, gender and age were strongly associated with number of permanent erupted teeth (p<0.05). In conclusion, our study demonstrated that timing of permanent tooth emergence is associated with overweigh/obesity in children from Manaus, Brazil.

Timing of permanent tooth emergence is associated with overweight/obesity in children from the amazon region

Abstract The aim of this study was to evaluate the association between timing of permanent tooth emergence with overweight and obesity in children from Brazilian Amazon region. The studied population consisted of 192 children, 09 to 12 year-old, from public schools at Manaus, Amazonas-Brazil. Clinical examination was performed and the tooth emergence was evaluated according to the number of permanent erupted teeth. Body mass index z-score was calculated. For the statistical analysis 'Overweight/obese' group was compared with 'Normal weight' group in a case to control ratio 1:2. The t-test based on age was used for means comparison between the groups. A linear regression analysis using age and gender as co-variants was used. The established alpha was 5%. One hundred twenty-seven children were classified as normal weight and 65 were classified as overweight/obese (49 were overweight and 16 were obese). Overweight/obesity condition was associated with the gender, in which boys had a higher chance to present higher weight conditions (OR=1.84; CI 95% 1.06-3.37; p=0.04). The mean number of permanent teeth was higher in the overweight/obesity group (p<0.001). Linear regression analysis demonstrated that nutritional status, gender and age were strongly associated with number of permanent erupted teeth (p<0.05). In conclusion, our study demonstrated that timing of permanent tooth emergence is associated with overweigh/obesity in children from Manaus, Brazil.

Resumo O objetivo deste estudo foi avaliar se a erupção dentária está associada com sobrepeso/obesidade em crianças da região Amazônica brasileira. A população estudada foi composta por 192 crianças, de 9 a 12 anos, de escolas públicas de Manaus, Amazonas-Brasil. O exame clínico foi realizado e a erupção dentária foi avaliada de acordo com o número de dentes permanentes irrompidos. O índice de massa corporal escore-z foi calculado. Para a análise estatística, comparou-se o grupo "sobrepeso / obesidade" com o grupo "peso normal" em uma proporção de controle 1: 2. O teste t baseado na idade foi utilizado para comparação das médias entre os grupos. Uma análise de regressão linear usando idade e sexo como co-variáveis foi utilizada. O alfa estabelecido foi de 5%. Cento e vinte e sete crianças foram classificadas com peso normal e 65 foram classificados com sobrepeso / obesidade (49 com sobrepeso e 16 com obesidade). A condição de sobrepeso / obesidade associou-se ao gênero, no qual os meninos tiveram maior chance de apresentar condições de maior peso (OR = 1,84; IC 95% 1,06-3,37; p = 0,04). O número médio de dentes permanentes irrompidos foi maior no grupo sobrepeso / obesidade (p <0,001). A análise de regressão linear demonstrou que o estado nutricional, sexo e idade foram fortemente associados ao número de dentes permanentes irrompidos (p <0,05). Concluindo, nosso estudo demonstrou que o momento da erupção dos dentes permanentes é associado com sobrepeso / obesidade em crianças de Manaus, Brasil.

Luxação extrusiva de um incisivo central Permanente jovem: relato de caso clínico / Extrusive luxation of an immature permanent central incisor: clinical case report

Objetivo: O objetivo deste artigo é apresentar o relato de um caso clínico de luxação extrusiva de dente permanente com rizogênese incompleta, onde não foi necessária a realização de intervenção endodôntica. Relato de caso: Paciente de 6 anos de idade compareceu ao serviço de urgência da Policlínica Odontológica da Universidade do Estado do Amazonas (UEA) para atendimento após queda durante atividade de lazer, apresentando traumatismo direto na boca. Foi informado durante a consulta inicial que o incidente havia ocorrido há cerca de três dias, e que o atendimento imediato logo após o trauma foi realizado em um Serviço de Pronto Atendimento, porém, nenhum tipo de procedimento na cavidade oral foi realizado. Após exames clínico e radiográfico observou-se que o dente 21 apresentava deslocamento parcial para fora do alvéolo dentário no sentido axial, com alteração da oclusão, dor local à palpação e mobilidade dentária. Foi realizada profilaxia da área afetada, e anestesia do dente luxado e tecidos adjacentes. O reposicionamento do dente foi realizado em seguida, pressionando-o e tracionando-o de forma suave e contínua até a sua correta posição dentro do alvéolo. A área afetada foi limpa com gaze estéril embebida em soro fisiológico, e foi instalada uma contenção rígida confeccionada com fio ortodôntico e resina composta. Conclusão: O reposicionamento da maneira adequada do dente traumatizado dentro do alvéolo dentário, num período de tempo hábil, seguido de sua proservação, permitiram a manutenção da vitalidade do tecido pulpar, e consequentemente, o desenvolvimento do segmento radicular.

Objective: The objective of this article is to present a clinical case of extrusive luxation of an immature permanent tooth, with no endodontic management. Case report: A 6-year-old patient was provided to emergency treatment at the State University of Amazonas, as a result of a fall, with a direct trauma to the mouth. It was informed during the initial consultation that the incidente has occurred three days after. Emergency examination had been carried out by an Emergency Service; however, any type of procedure in the oral cavity was performed in ths occasion. After clinical and radiographic examinations, it was observed that tooth 21 presented partial displacement from the alveolar socket in the axial direction, with occlusion alteration, local pain to palpation and dental mobility. Cleaning of the affected area and anesthesia of the dislocated tooth and adjacent tissues were performed. Then, tooth repositioning was performed by pressing and tracing it smoothly and continuously until its correct position within the alveolar socket. The affected area was cleaned with sterile gauze soaked in saline solution, and a rigid containment made of orthodontic wire and composite resin was installed. Conclusion: A proper repositioning of the traumatized tooth within the alveolar socket, followed by its clinical followup, allowed the pulp tissue to remain vital, and consequently, the complete development of the root portion

Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children.

OBJECTIVE: This replication study aimed to evaluate an association between caries experience and polymorphisms in DEFB1 and miRNA202 in two different Brazilian groups. DESIGN: The population consisted in 312 Brazilian children. Genomic DNA for was extracted from buccal cells isolated from saliva. The genotyping analysis of the polymorphisms in DEFB1 and miRNA202 was performed by real-time polymerase chain reactions. The associations between caries experience, genotype and allele distribution was performed, with an alpha of 0.05. RESULTS: A statistical significant difference was observed between allele distribution and the polymorphism rs12355840 in the miRNA202 for permanent dentition in the Manaus group, in which individuals that carry the allele C had almost three times more chance to have caries (p = .021; OR = 2.7, 95% CI = 1.1-6.7). In the Ribeirão Preto group there was a statistical significant difference for the polymorphism rs11362 in the DEFB1 for both dentition in alleles (p = .043) and genotype (p = .020) distributions. The T allele increased in two times the chance to have caries (OR = 2.03; 95% CI = 1.05-4.07). CONCLUSION: In conclusion, the allelic distribution of the polymorphism rs12355840 in miRNA202 was associated with caries experience in the Manaus group. In the Ribeirão Preto group, the allelic and genotypic distributions in the polymorphism rs11362 in DEFB1 were associated with caries experience.

A educação em saúde como medida de prevenção e promoção da saúde bucal / Health education as a measure of prevention and promotion of oral health

O objetivo deste estudo foi conhecer os projetos desenvolvidos na área de educação em saúde nas escolas públicas, bem como aceitação de pais, educadores e alunos. Foi feito um estudo epidemiológico quantitativo. A população estudada foi constituída de crianças do sexto ao nono ano do ensino fundamental, seus respectivos responsáveis e professores. A maioria dos participantes aceitaram o projeto de educar em saúde. Os professores afirmaram que 70% dos alunos demonstram interesse pelo tema de educação em saúde bucal. Os entrevistados se puseram dispostos a participar de um programa em conjunto envolvendo pais, professores e alunos. Todos os professores participantes consideraram essa integração importante, podendo ocorrer, principalmente, através de projetos pedagógicos. O grupo estudado, além de obter mais conhecimento em saúde bucal, também destacou a importância da presença dos alunos de Odontologia da UEA na escola...

The objective of this study was to get to know health education projects developed in public schools, as well as to assess acceptance of parents, educators, and students. The study samples was composed by students from sixth to ninth grade; their guardians and teachers. Most participants accepted well the health education project. Teachers stated that 70% of students were interested in oral health education. Respondents stood ready to participate in a joint program between parents, teachers and students. All teachers considered this integration important, and pointed out the possibility of it occurrence mainly through educational projects. The studied group, gained knowledge on oral health, and highlighted the importance of the presence of dentistry students from UEA at the school...

Transverse measurements of the jaws of patients with a predominance of nose and mouth breathing in children between 6 and 14 years of age / Medidas transversais dos maxilares de pacientes com predominância de respiração nasal e bucal em crianças de 6 a 14 anos

Objectives: To determine and study the occurrence of possible growth and development anomalies of the craniofacial complex in patients aged between 6 and 14, diagnosed with predominantly mouth and nose breathing patterns, and without having received prior dental treatment. Methods: We performed transverse jaw measurements on 103 patients between 6 and 14 years of age, registered for orthodontic treatment in theMilitary Hospital in the Brasilia area. Divided into two groups: Group 1, patients with predominance of nose breathing and Group 2, patientswith predominance of mouth breathing. Results: There were no statistically significant differences between the upper and lower intercanine or upper intermolar distances, between groups 1 and 2. A smaller statistically significant difference was observed in group 2 when evaluating the lower intermolar distance. Conclusion: The group of mouth breathers showed statistically lower values in the lower jaw, thus suggesting a contraction in the posterior arch of patients diagnosed with this breathing pattern.

Objetivos: Verificar e estudar a ocorrência de possíveis anomalias de crescimento e desenvolvimento do complexo craniofacial, de pacientes diagnosticados com o padrão de respiração predominante bucal e nasal, na faixa etária de 6 a 14 anos de idade, sem tratamento ortodôntico prévio.Métodos: Foram realizadas as medidas transversais maxilares em 103 pacientes na faixa etária dos 6 a 14 anos de idade, inscritos para tratamento ortodôntico no Hospital Militar de Área de Brasília. Divididos em dois grupos: 1 pacientes com predominância de respiração nasal e 2 pacientes com predominância de respiração bucal. Resultados: Não foram observadas diferenças estatisticamente significativas entre as distâncias inter-caninos superior e inferior, inter-molares superior, entre os grupos 1 e 2. Foi observada diferença estatisticamente significativa menor no grupo 2 quando avaliada a distância inter-molar inferior. Conclusão: O grupo de pacientes respiradores bucais apresentou valores estatisticamente menores na arcada inferior, sugerindo desta forma uma contração posterior na arcada dos pacientes diagnosticados com este padrão de respiração.

Etiology and treatment of anterior open bite / Etiologia e tratamento da mordida aberta anterior

The term anterior open bite, which means no contact between anterior teeth, stands out in current orthodontic by the complexity of the treatment, associated with high levels of instability and recurrence. The purpose of this study is to emphasize that early etiological diagnosis is essential to the successful outcome of the technical intervention. The bibliographical study shows that, once the malocclusion in deciduous and mixed dentition is diagnosed, it simplifies the aparatology that is used, decreases the treatment time and conditions are created for a possible self-correction. In the permanent dentition, the authors recommend the removal of the etiological factor and the control of the vertical growth. The diversity of causes requires a multidisciplinary therapeutic approach.

A expressão mordida aberta anterior, que designa ausência de contato entre os dentes anteriores, destaca-se na ortodontia atual pela complexidade do tratamento, associada a altos níveis de instabilidade e recidiva. O objetivo deste trabalho é enfatizar que o diagnóstico etiológico precoce é fundamental para o bom resultado da intervenção técnica. O estudo bibliográfico mostra que, diagnosticada a maloclusão na dentadura decídua e mista, simplifica-se a aparatologia utilizada, diminui-se o tempo de tratamento e criam-se condições para uma possível autocorreção. Na dentadura permanente, os autores recomendam a remoção do fator etiológico e o controle do crescimento vertical. A diversidade de causas requer abordagem terapêutica multidisciplinar.

Palatal expansion and maxillary protaction: case report / Disjunção palatal e protração maxilar: relato de caso clínico

Early Class III malocclusion correction is an important factor for the patient, whereas it can avoid later surgical procedures. This malocclusion causes esthetic and functional damage; as well it can cause disturbances in patient's social life and psychological problems. This paper presents a clinical case report of palatal expansion followed by maxillary protraction, occurred at University Paulista, Brasília-DF. It was used a hyrax expansor with vestibular hooks and PETIT´s facial mask. Clinical results were considered satisfatories.

A correção precoce da Classe III é de suma importância, uma vez que previne futura correção cirúrgica. Esta maloclusão acarreta prejuízos estéticos e funcionais ao paciente, levando a problemas de ordem psicológica, podendo gerar o aparecimento de transtornos nas relações interpessoais e no convívio social. Este trabalho relata um caso clínico de disjunção palatal seguida de protração maxilar, ocorrido na Clínica de Ortodontia/Odontopediatria da Universidade Paulista, Brasília-DF. Foram utilizados um expansor Hyrax com ganchos vestibulares e máscara facial de PETIT. Os resultados clínicos obtidos foram considerados satisfatórios.

Assessment of treatment for functional posterior cross-bites in patients at the deciduous dentition phase.

The aim of this study was to clinically assess the results of treatment for functional posterior cross-bites by means of selective grinding in individuals at the deciduous dentition phase over a period of 12 months. From a total of 1,011 children examined in the 2-to-6-year age bracket, 26 with functional posterior cross-bites were selected. The sample was divided into 2 groups of 13 children each, group 1 receiving the treatment proposed and group 2 serving as the control group. Treatment was followed up by exercises designed to alter the children's muscular memory. The results showed that correction of functional posterior cross-bite was achieved for all the children treated, the correction remaining stable 12 months later. No self-correction of malocclusion occurred among the control group.

Estudo longitudinal comparativo das relações terminais dos segundos molares decíduos / Comparative longitudinal study of the terminal relations of the second deciduous molars

O objetivo deste estudo foi acompanhar as mudanças que ocorrem com as relações terminais dos segundos molares decíduos antes da erupção dos primeiros molares permanentes até a intercuspidação destes últimos. Foram examinadas 721 criança, com idade compreendida entre 4 e 5 anos, na fase de dentição primária, e selecionadas 60 para participarem do estudo. A amostra foi dividida em três grupos de 20 crianças cada um, sendo 10 do sexo masculino e 10 do feminino, de acordo com a classificação das relações terminais proposta por Baume (1950). Foi verificado que no grupo em que as crianças apresentavam os segundos molares decíduos em plano terminal vertical 40% mantiveram esta mesma relação, enquanto 50% modificaram este padrão oclusal, passando a apresentar os segundos molares decíduos em degrau mesial para a mandíbula e 10% em degrau distal. No grupo em que a relação terminal dos segundos molares decíduos apresentava-se em degrau mesial para a mandíbula, 45% mantiveram esta mesma relação terminal enquanto 55% progrediram para uma relação de topo. Por último, no grupo que apresentava os segundos molares decíduos em degrau distal para a mandíbula, 30% mantiveram este padrão oclusal, 60% modificaram o padrão oclusal para uma relação de topo e 10% para degrau mesial. Tais resultados sugerem que ocorrem modificações significantes nas relações terminais dos segundos molares decíduos, após a erupção dos primeiros molares permanentes.

Assessment of treatment for functional posterior cross-bites in patients at the deciduous dentition phase

O objetivo deste estudo foi avaliar clinicamente o resultado do tratamento das mordidas cruzadas posteriores de origem funcional, através de desgaste seletivo, em indivíduos na fase de dentição decídua, durante o período de 12 meses. Foram examinadas 1011 crianças, com idades entre 2 e 6 anos, selecionando-se 26 indivíduos que apresentavam mordida cruzada posterior funcional. A amostra foi dividida em 2 grupos de 13 crianças cada, sendo o grupo 1 o que recebeu o tratamento proposto e o grupo 2 servindo como controle. Após o tratamento, foram realizados exercícios com o objetivo de modificar a memória muscular da criança. Os resultados possibilitaram constatar que houve correção da mordida cruzada posterior funcional em todas as crianças tratadas, ocorrendo estabilidade da correção após 12 meses. O grupo controle não apresentou nenhum caso de autocorreção da maloclusão.

Granuloma peroférico de células gigantes / Peripheral giant cell granuloma

Este trabalho apresenta as características clínicas, radiográficas e histopatológicas do granuloma periférico de células gigantes, relatando um caso clínico ocorrido em um paciente do sexo feminino, de 26 anos de idade. É discutido o diagnóstico diferencial com outras lesões

Fendas labiais: uma revisão bibliográfica / Cleft lip: a literature review

Os autores revisaram a literatura disponível com a finalidade de demonstrar a prevalência da fenda labial, buscando estabelecer os prováveis fatores que a influenciam, verificando a predileção por sexo e raça